PharmaCircle™ - TOP SALES

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Top 100 Drug Sales - 2009

	Product	world(M$)	Change	usa(M$)	Change
1	Lipitor Tablets Pfizer Inc., Astellas Pharma Inc., Almirall	12651.0	2.0%	5667.0	-11.7%
2	Plavix Tablets Sanofi-Aventis, Bristol-Myers Squibb Co.	9493.0	4.0%	5556.0	11.4%
3	Advair Diskus Group GlaxoSmithKline Plc, Almirall	7792.3	4.4%	3734.1	-4.2%
4	Enbrel Prefilled Syringe Group Wyeth, Takeda Pharmaceutical Co. Ltd., Amgen Inc.	6067.0	-1.0%	3283.0	-3.2%
5	Diovan Tablets Group Novartis AG	6013.0	4.5%	2492.0	3.5%
6	Remicade Schering-Plough Corp., Mitsubishi Tanabe Pharma Corporation, Johnson and_ Johnson	5942.0	11.6%	3088.0	9.0%
7	AVASTIN Injection Roche, Genentech Inc.	5745.2	18.4%	3060.9	12.2%
8	Rituxan Roche, Genentech Inc.	5620.5	5.1%	2665.0	2.9%
9	HUMIRA Prefilled Syringe Group Abbott Laboratories Inc., Eisai Co. Ltd	5488.0	17.6%	2519.0	10.5%
10	Seroquel Tablets Group AstraZeneca Plc	5110.0	9.4%	3416.0	11.7%
11	NEXIUM I.V. Group AstraZeneca Plc	4959.0	-4.9%	2835.0	-9.4%
12	Zyprexa Tablets Group Eli Lilly and_ Co.	4916.0	4.5%	2332.0	4.2%
13	HERCEPTIN Injection Roche	4862.4	5.7%	1446.0	4.4%
14	Toledomin Asahi Kasei Pharma	4800.0	-20.8%	0.0
15	Singulair Tablets Group Merck and_ Co Inc., Kyorin Pharmaceutical	4659.0	6.9%	3044.0	7.2%
16	Crestor Tablets AstraZeneca Plc	4502.0	20.1%	2100.0	20.1%
17	Lantus Vials Group Sanofi-Aventis	4293.9	18.4%	2661.4	22.0%
18	Actos Tablets Takeda Pharmaceutical Co. Ltd.	4072.3	14.5%	3150.8	12.7%
19	Gleevec Capsules Group Novartis AG	3944.0	6.9%	1088.0	17.1%
20	Cozaar Tablets Group Merck and_ Co Inc.	3561.0	0.1%	1321.0	5.6%
21	Aricept Tablets Group Eisai Co. Ltd	3359.5	16.7%	2020.6	13.2%
22	Neulasta Group Amgen Inc.	3355.0	1.1%	2527.0	0.9%
23	Spiriva Group Boehringer Ingelheim	3351.5	11.7%	0.0
24	Cipralex Tablets Group H Lundbeck A/S, Forest Laboratories Inc, Almirall	3351.0	0.4%	2264.0	-2.9%
25	Cymbalta Capsules Eli Lilly and_ Co.	3075.0	12.3%	2552.0	11.7%
26	Taxotere Sanofi-Aventis	3035.0	4.3%	1152.9	8.6%
27	Atacand Tablets Group AstraZeneca Plc, Takeda Pharmaceutical Co. Ltd., Almirall	2990.0	3.1%	263.0	0.4%
28	Tamiflu Capsules Group Roche	2954.8	81.4%	836.6	53.7%
29	Lyrica Capsules Pfizer Inc.	2840.0	9.4%	1504.0	3.7%
30	Copaxone Injection Teva Pharmaceutical Industries Ltd., Sanofi-Aventis	2826.0	20.0%	1919.0	28.2%
31	Effexor Tablets Group Wyeth	2814.0	-39.6%	2300.0	-16.8%
32	Aranesp Group Amgen Inc.	2652.0	-18.3%	1251.0	-32.0%
33	Abilify Tablets Group Bristol-Myers Squibb Co., Otsuka Pharmaceutical Co., Ltd.	2592.0	16.9%	2082.0	19.5%
34	Epogen Amgen Inc.	2569.0	4.4%	2569.0	4.4%
35	Flomax Capsules Group Astellas Pharma Inc., Boehringer Ingelheim	2531.0	18.5%	1971.3	22.1%
36	Truvada Tablets Gilead Sciences Inc.	2490.0	15.4%	1178.0	15.8%
37	Olmetec Group Daiichi Sankyo Co Ltd.	2451.9	21.4%	951.5	9.3%
38	Prevnar Vaccine Wyeth	2434.0	-11.6%	1029.0	-14.7%
39	Prevacid Delayed Release Capsules Group Takeda Pharmaceutical Co. Ltd.	2422.0	-14.9%	934.3	-95.5%
40	Celebrex Capsules Pfizer Inc., Astellas Pharma Inc.	2383.0	-4.4%	1697.0	-7.2%
41	Atripla Tablets Gilead Sciences Inc.	2382.0	34.0%	1646.0	20.0%
42	Lucentis Novartis AG, Genentech Inc.	2327.0	24.3%	1106.2	20.9%
43	Avonex Biogen Idec Inc.	2323.0	5.2%	1406.0	9.2%
44	Symbicort SMART MDI Group AstraZeneca Plc	2294.0	12.6%	488.0	47.7%
45	Aprovel Tablets Group Sanofi-Aventis, Bristol-Myers Squibb Co., Shionogi and_ Co., Ltd.	2291.0	-22.7%	722.0	-1.8%
46	Eprex Johnson and_ Johnson	2245.0	-9.6%	1258.0	-5.9%
47	Zetia Tablets Schering-Plough Corp., Incyte Corp.	2244.0	-1.6%	1296.0	-9.2%
48	Rebif Syringe Group Merck Serono S.A.	2142.8	11.2%	0.0
49	Vytorin Tablets Schering-Plough Corp.	2112.0	-11.4%	1219.0	-25.3%
50	Prograf Capsules Group Astellas Pharma Inc.	2052.7	10.9%	820.9	-0.7%
51	VALTREX Caplets GlaxoSmithKline Plc	2026.0	-6.2%	1474.9	-6.2%
52	Norvasc Tablets Pfizer Inc.	1973.0	-13.7%	64.0	-18.8%
53	Humalog Mix50/50 Pen Group Eli Lilly and_ Co.	1959.0	11.4%	1208.0	16.6%
54	Micardis HCT Group Boehringer Ingelheim	1942.0	10.3%	0.0
55	JANUVIA Merck and_ Co Inc., Ono Pharmaceutical Co., Ltd.	1922.0	27.3%	1404.0	20.9%
56	ARIMIDEX Tablets AstraZeneca Plc	1921.0	3.3%	878.0	14.1%
57	Viagra tablets Pfizer Inc.	1892.0	-2.2%	962.0	6.8%
58	Ambien Tablets Group Sanofi-Aventis	1819.0	22.4%	773.7	-1.1%
59	YAZ Group Bayer AG	1781.7	2.0%	745.9	-8.1%
60	Xalatan Ophthalmic Solution 0.005% Group Pfizer Inc.	1737.0	-0.5%	576.0	6.9%
61	Revlimid Capsules Celgene Corp.	1710.0	22.5%	0.0
62	Alimta Eli Lilly and_ Co.	1706.0	32.3%	816.0	31.1%
63	Protonix Delayed Release Tablets Group Nycomed	1695.3	-127.2%	904.0	10.8%
64	Betaseron Betaject Group Bayer AG	1692.5	3.4%	667.8	18.7%
65	Erbitux Merck Serono S.A., Bristol-Myers Squibb Co.	1649.0	-1.6%	683.0	-9.7%
66	Aciphex Tablets Eisai Co. Ltd	1617.2	8.5%	919.3	-2.9%
67	CIALIS Tablets Eli Lilly and_ Co.	1559.0	7.3%	623.0	13.5%
68	FLOXIN Tablets Group Johnson and_ Johnson	1550.0	-2.6%	1478.0	-2.2%
69	Lupron Depot 7.5 mg Group Abbott Laboratories Inc., Takeda Pharmaceutical Co. Ltd., Orion Corp.	1534.0	0.0%	540.0	-2.0%
70	PEGASYS Injection Group Roche	1528.2	3.7%	373.0	4.7%
71	Fluzone Prefilled Syringes Group Sanofi-Aventis	1480.6	28.9%	861.6	23.9%
72	Zometa Injection Novartis AG	1469.0	5.9%	718.0	7.2%
73	NAMENDA Tablets Group H Lundbeck A/S, Forest Laboratories Inc	1466.0	11.8%	1061.0	12.2%
74	Velcade Injection Johnson and_ Johnson, Takeda Pharmaceutical Co. Ltd.	1458.0	21.9%	535.1	34.5%
75	CELLCEPT Tablets Group Roche	1455.2	-29.9%	506.9	-82.2%
76	Toprol-XL Tablets AstraZeneca Plc	1443.0	44.1%	964.0	69.4%
77	NeoRecormon Vials Group Roche	1440.4	-10.9%	0.0
78	Risperdal Consta Johnson and_ Johnson	1425.0	8.1%	519.0	12.1%
79	Reyataz Capsules Bristol-Myers Squibb Co.	1401.0	7.8%	726.0	8.1%
80	Eril Injection Asahi Kasei Pharma	1400.0	0.0%	0.0
81	Tracleer Tablets Actelion Ltd.	1389.7	16.2%	0.0
82	Pandemrix GlaxoSmithKline Plc	1382.5		292.8
83	Proquad Group	1369.0		1288.0
84	Kaletra Soft Gel Capsules Group Abbott Laboratories Inc.	1366.0	-7.9%	446.0	-15.0%
85	Gemzar Eli Lilly and_ Co.	1363.0	-26.2%	747.0	1.6%
86	DAPTACEL Group Sanofi-Aventis	1349.5	18.7%	0.0
87	ELOXATIN Sanofi-Aventis, Yakult Honsha Co., Ltd.	1348.1	-42.9%	943.8	-43.6%
88	Tricor NanoCrystal Tablets Group Abbott Laboratories Inc.	1337.0	-0.3%	1337.0	-0.3%
89	NovoSeven Group Novo Nordisk A/S	1323.9	7.4%	0.0
90	EVISTA Tablets 60 mg Eli Lilly and_ Co., Chugai Pharmaceutical Co., Ltd., Daiichi Sankyo Co Ltd.	1322.0	-1.3%	682.0	-2.7%
91	Botox Injection Allergan Inc.	1311.0	0.0%	0.0
92	Pulmicort Inhaler Group AstraZeneca Plc	1310.0	-14.1%	804.0	-22.1%
93	Neupogen Group Amgen Inc., Aviron	1288.0	-4.1%	901.0	0.6%
94	Sustiva Capsules Bristol-Myers Squibb Co.	1277.0	10.0%	823.0	12.0%
95	KEPPRA Oral Solution Group UCB Pharma	1272.8	-42.2%	446.1	-146.1%
96	Femara Tablets Novartis AG, Chugai Pharmaceutical Co., Ltd.	1266.0	10.8%	572.0	15.6%
97	Kogenate FS Bayer AG	1238.0	2.1%	348.5	32.6%
98	NovoMix 30 FlexPen Group Novo Nordisk A/S	1216.6	11.8%	0.0
99	Flovent-HFA/Flixotide EvoHaler Group GlaxoSmithKline Plc	1213.4	-0.4%	620.0	8.0%
100	AVANDIA Tablets Group GlaxoSmithKline Plc	1207.1	-20.0%	665.4	-17.4%